Abstract #1205

Recombinant expression and synthesis of a targeted human contrast agent for quantitative renal MRI

Kasey C Emoto¹, Edwin Baldelomar², Maria Veronica Clavijo-Jordan³, Jennifer R Charlton⁴, Courtnie Yokono⁵, and Kevin M Bennett⁶

¹Biology, University of Hawaii at Manoa, Honolulu, HI, United States, ²Physics, University of Hawaii at Manoa, Honolulu, HI, United States, ³Martinos Center for Biomedical Imaging, Harvard University, Charlestown, MA, United States, ⁴Pediatrics, University of Virginia, Charlottesville, VA, United States, ⁵Bioengineering, University of Hawaii at Manoa, Honolulu, HI, United States, ⁶Washington University in St. Louis, Clayton, MO, United States

This study demonstrates the synthesis and use of a human recombinant cationic ferritin nanoparticle, synthesized in ecoli, as contrast agent for targeted renal imaging. Injected nanoparticles accumulated in the glomerular basement membrane in a mouse, allowing measurement of nephron endowment using gradient echo imaging and automated segmentation. Use of human recombinant contrast agents may allow improved biocompatibility for clinical translation.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.