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Abstract #1205

Recombinant expression and synthesis of a targeted human contrast agent for quantitative renal MRI

Kasey C Emoto1, Edwin Baldelomar2, Maria Veronica Clavijo-Jordan3, Jennifer R Charlton4, Courtnie Yokono5, and Kevin M Bennett6

1Biology, University of Hawaii at Manoa, Honolulu, HI, United States, 2Physics, University of Hawaii at Manoa, Honolulu, HI, United States, 3Martinos Center for Biomedical Imaging, Harvard University, Charlestown, MA, United States, 4Pediatrics, University of Virginia, Charlottesville, VA, United States, 5Bioengineering, University of Hawaii at Manoa, Honolulu, HI, United States, 6Washington University in St. Louis, Clayton, MO, United States

This study demonstrates the synthesis and use of a human recombinant cationic ferritin nanoparticle, synthesized in ecoli, as contrast agent for targeted renal imaging. Injected nanoparticles accumulated in the glomerular basement membrane in a mouse, allowing measurement of nephron endowment using gradient echo imaging and automated segmentation. Use of human recombinant contrast agents may allow improved biocompatibility for clinical translation.

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