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Abstract #1208

Non-Invasive Assessment of Intratumor Heterogeneity in Clear Cell Renal Cell Carcinoma using Quantitative MRI-Derived Texture Features

Durga Udayakumar1,2, Durgesh Dwivedi1, Ze Zhang3, Yin Xi1,3, Tao Wang3, Ananth Madhuranthakam1,2, Payal Kapur4,5,6, Asghar Hajibeigi1, Allison Joyce7, Qurratulain Yousuf6,7, Michael Fulkerson1, Alberto Diaz de Leon1, Matthew Lewis1, Jeffrey Cadeddu5,6, Aditya Bagrodia5, Vitali Margulis5,6, James Brugarolas6,7, and Ivan Pedrosa1,2,6

1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3Clinical Science, UT Southwestern Medical Center, Dallas, TX, United States, 4Pathology, UT Southwestern Medical Center, Dallas, TX, United States, 5Urology, UT Southwestern Medical Center, Dallas, TX, United States, 6Kidney Cancer Program, UT Southwestern Medical Center, Dallas, TX, United States, 7Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States

Intra and inter-tumor heterogeneity pose a challenging task for predicting tumor behavior due to the limited understanding of the molecular mechanism of clear cell renal cell carcinoma (ccRCC) development. The purpose of the present study was to correlate non-invasive quantitative measures of heterogeneity on MR imaging with histopathologic signatures of aggressiveness and gene expression heterogeneity in ccRCC. MRI derived Haralick texture features offer objective, quantitative measures of ccRCC aggressiveness, which can help compensate for the limitations of percutaneous biopsies in the tissue characterization of larger, heterogeneous tumors and assist in the implementation of active surveillance and neoadjuvant therapy protocols.

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