Abstract #1221

Dynamic BOLD Responses of Renal Tissues to interleaved Hypoxia and Hyperoxia in Healthy Rats as Measured by MRI at 7T

Kaixuan Zhao¹, Yingjie Mei^1,2, Guixiang Yang¹, Zhengce Wang¹, Lili Zhou³, Ed X. Wu⁴, and Yanqiu Feng¹

¹School of Biomedical Engineering, Guangdong Provincial Key Laborary of Medical Image Processing, Southern Medical University, Guang Zhou, China, ²Philips Healthcare, Guang Zhou, China, ³State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou, China, Guang Zhou, China, ⁴Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong,Pokfulam,Hong Kong SAR,China, Hong Kong, China

Renal oxygen status is tightly correlated with renal (patho)physiology. How the renal oxygen is regulated in response to interleaved hypoxia and hyperoxia has not been well investigated. In this work we utilized dynamic BOLD MRI with temporal resolution of 9 seconds to track the renal tissues oxygen responses in healthy rats, thereafter, characterizing the renal oxygen changes by a mathematic model. In the experiment, significant T2* overshot was observed in outer medulla at the initial stage of re-oxygenation. Significant difference of model parameters compared among renal cortex, outer medulla and inner medulla was observed.

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