Abstract #1222

Spin-lock Relaxation Rate Dispersion Reveals Spatiotemporal Changes Associated with Tubulointerstitial Fibrosis in Murine Kidney

Feng Wang¹, Daniel C. Colvin¹, Suwan Wang², Hua Li¹, Raymond C. Harris², Ming-Zhi Zhang², and John C. Gore¹

¹Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ²Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN, United States

Currently there are no reliable non-invasive means for assessing the severity and progression of fibrosis in kidneys. Here we evaluate spin-lock MR imaging with different locking fields for detecting progressive renal fibrosis in an hHB-EGF^Tg/Tg mouse model. We fit the dispersion of spin-lock relaxation rates R_1ρ at different locking fields (frequencies) to a model of exchanging water pools and assessed the value of the derived quantities for detecting tubulointerstitial fibrosis in kidney, including the transverse relaxation rate (R₂), the asymptotic value of R_1ρ at high locking frequency (R_1ρ^inf), an exchange rate-weighted parameter S_ρ, and the inflection frequencies ω_infl in the dispersion.

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