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Abstract #1222

Spin-lock Relaxation Rate Dispersion Reveals Spatiotemporal Changes Associated with Tubulointerstitial Fibrosis in Murine Kidney

Feng Wang1, Daniel C. Colvin1, Suwan Wang2, Hua Li1, Raymond C. Harris2, Ming-Zhi Zhang2, and John C. Gore1

1Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 2Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN, United States

Currently there are no reliable non-invasive means for assessing the severity and progression of fibrosis in kidneys. Here we evaluate spin-lock MR imaging with different locking fields for detecting progressive renal fibrosis in an hHB-EGFTg/Tg mouse model. We fit the dispersion of spin-lock relaxation rates R at different locking fields (frequencies) to a model of exchanging water pools and assessed the value of the derived quantities for detecting tubulointerstitial fibrosis in kidney, including the transverse relaxation rate (R2), the asymptotic value of R at high locking frequency (Rinf), an exchange rate-weighted parameter Sρ, and the inflection frequencies ωinfl in the dispersion.

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