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Abstract #1223

Magnetization Transfer Imaging is Insensitive to Decrease in Renal Perfusion: A Graded Ischemia Study on Swine

Kai Jiang1, Christopher M. Ferguson1, John R. Woollard1, James D. Krier1, Xiangyang Zhu1, and Lilach O. Lerman1

1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States

The impact of renal perfusion on magnetization transfer imaging (MTI) was evaluated on seven pigs that underwent consecutive MRI at baseline, 50%, 75%, and 100% acute renal artery stenosis as well as reperfusion. Renal perfusion, R2*, apparent diffusion coefficient (ADC), stiffness, and MT ratio (MTR) were measured. During graded ischemia, decline in renal perfusion was accompanied with elevated R2*, decreased ADC and stiffness. In contrast, no change was observed in the MTR. In conclusion, MTI is insensitive to decrease in renal perfusion and may offer a relatively reliable technique for measurement of renal structural changes.

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