We used in vivo contrast-enhanced MRI to evaluate how vagus nerve stimulation (VNS) could modulate and coordinate the motility of the antrum and pylorus. We tested cervical VNS with different settings (afferent or efferent) and parameters (amplitude, duration, and frequency) and found differential effects on the motility. Our results suggest that selective stimulation of vagal afferent using a monophasic pulse train is a more effective strategy to facilitate and coordinate the antro-pyloric motility than selective stimulation of the vagal efferent. These results could shed lights on the selection of VNS settings for modulating gastric functions.
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