Abstract #1225

Fetal Hepatic Flow in Sheep Assessed using 4D flow MRI

Eric Schrauben¹, Brahmdeep Saini^2,3, Jack R.T. Darby⁴, Stacey Holman⁴, Jia Yin Soo⁴, Mitchell C Lock⁴, Sunthara R Perumal⁵, Michael Seed^6,7, Janna L Morrison⁴, and Christopher K Macgowan^1,8

¹Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada, ²Heart Centre, The Hospital for Sick Children, Toronto, ON, Canada, ³Faculty of Medicine, University of Toronto, Toronto, ON, Canada, ⁴Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia, ⁵Preclinical Imaging and Research Laboratories, South Australian Health and Medical Research Institute, Adelaide, Australia, ⁶Cardiology, The Hospital for Sick Children, Toronto, ON, Canada, ⁷Paediatrics, University of Toronto, Toronto, ON, Canada, ⁸Medical Biophysics, University of Toronto, Toronto, ON, Canada

Assessment of fetal hepatic flow poses difficult technical problems due to the small nature of vessels, slow blood flow within the liver, and sources of motion present in utero. Here, 4D flow MRI is coupled with specialized animal preparation to capture 3D fetal hepatic hemodynamics in a late gestation sheep model of human pregnancy. Full vasculature segmentation, fetal liver shunt visualization, and comprehensive measurement of hepatic circulation is demonstrated.

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