First-pass contrast-enhanced myocardial perfusion imaging is a useful noninvasive tool to evaluate patients with coronary artery disease, but current techniques are still limited in spatial-temporal resolution, ventricular coverage and absolute quantification which reduces the sensitivity to detect perfusion differences between the endocardium and epicardium and quantify ischemic burden. In this study, we designed a dual-density dual-contrast spiral pulse sequence to achieve quantitative ultra-high resolution first-pass spiral perfusion imaging with whole heart coverage at 3T and further tested in 9 patients with suspected CAD undergoing cardiac catheterization.
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