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Abstract #1237

Simultaneous 13N-Ammonia and gadolinium first-pass myocardial perfusion with hybrid PET-MR imaging: a clinical feasibility study.

Muhummad Sohaib Nazir1, Sarah-May Gould1, Xenios Milidonis1, Eliana Reyes1, Tevfik F. Ismail1, Radhouene Neji1,2, Sébastien Roujol1, Jim O'Doherty1, Hui Xue3, Sally Barrington1, Reza Razavi1, Paul Marsden1, Peter Kellman3, Sven Plein1,4, and Amedeo Chiribiri1

1Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Siemens Healthcare, Camberley, United Kingdom, 3National Heart, Lung and Blood Institute, Bethesda, MD, United States, 4Leeds Institute of Cardiovascular and Metabolic Medicine, Leeds, United Kingdom

Hybrid PET-MR imaging allows simultaneous measurement of myocardial blood flow (MBF) under identical physiological conditions. We sought to determine feasibility of simultaneous 13N-Ammonia PET and dynamic contrast-enhanced cardiovascular magnetic resonance (CMR) in healthy volunteers. 13N-Ammonia and gadolinium contrast were administered simultaneously during adenosine stress. Mean global stress MBF values for PET and CMR were 2.58 ± 0.11ml/g/min and 2.60 ± 0.47ml/g/min respectively. On a per territory basis, there was a moderate correlation (r = 0.63, p=0.03) and CMR underestimated PET MBF by 0.34ml/g/min (95% limits of agreement -0.49 to +1.18). Future studies in patients with CAD is warranted.

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