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Abstract #1248

Nasopharyngeal Irradiation can Increase Signal Intensity on T1-Weighted MRI of the Dentate Nucleus in Patients with Nasopharyngeal Malignancies

Rongbiao Tang1, Mark Haacke2, Qingrou Wang1, Naying He1, Ke-min Chen1, and Fuhua Yan1

1Department of radiology, Rui Jin Hospital, Shanghai, China, 2Department of radiology, Wayne State University, Detroit, MI, United States

Patients with nasopharyngeal malignancies (NPM) are generally treated by nasopharyngeal irradiation. In order to evaluate curative effect, gadolinium-based contrast agents (GBCAs)-based MRI examinations are always performed repeatedly. Whether the nasopharyngeal irradiation affects the T1 signal intensity (SI) in DN remains unclear. 68 NPM patients and 68 suitable control patients were enrolled. We found that the uptake rate of gadolinium from the NPM was significantly higher than that from control patients. We speculated that the nasopharyngeal irradiation increases the T1 SI by the damage to the blood–brain barrier (BBB).

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