Abstract #1256

High-resolution Isotropic Whole Brain T2 Mapping with Model-based Super-resolution Reconstruction

Wajiha Bano^1,2, Gian Franco Piredda^3,4,5, Mike Davies¹, Ian Marshall², Mohammad Golbabaee⁶, Reto Meuli⁵, Tobias Kober^3,4,5, Jean-Philippe Thiran^4,5, and Tom Hilbert^3,4,5

¹School of Engineering, Institute for Digital Communications,University of Edinburgh, Edinburgh, United Kingdom, ²Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, ³Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁴LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁵Department of Radiology, University Hospital Lausanne (CHUV), Lausanne, Switzerland, ⁶Computer Science Department, University of Bath, Bath, United Kingdom

We propose a method to reconstruct 1-mm³ isotropic T2 maps based on multiple 2D multi-echo spin-echo (MESE) acquisitions. To compensate for the prolonged scan time due to multiple acquisitions, data were highly (10-fold) undersampled. The data was reconstructed by combining a classical super-resolution approach with an iterative model-based reconstruction. The method was tested on a phantom and four healthy volunteers. T2 values were compared against fully sampled MESE data. The proposed technique allows the assessment of T2 values in brain structures at high isotropic resolution.

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