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Abstract #1256

High-resolution Isotropic Whole Brain T2 Mapping with Model-based Super-resolution Reconstruction

Wajiha Bano1,2, Gian Franco Piredda3,4,5, Mike Davies1, Ian Marshall2, Mohammad Golbabaee6, Reto Meuli5, Tobias Kober3,4,5, Jean-Philippe Thiran4,5, and Tom Hilbert3,4,5

1School of Engineering, Institute for Digital Communications,University of Edinburgh, Edinburgh, United Kingdom, 2Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, 3Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 4LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 5Department of Radiology, University Hospital Lausanne (CHUV), Lausanne, Switzerland, 6Computer Science Department, University of Bath, Bath, United Kingdom

We propose a method to reconstruct 1-mm3 isotropic T2 maps based on multiple 2D multi-echo spin-echo (MESE) acquisitions. To compensate for the prolonged scan time due to multiple acquisitions, data were highly (10-fold) undersampled. The data was reconstructed by combining a classical super-resolution approach with an iterative model-based reconstruction. The method was tested on a phantom and four healthy volunteers. T2 values were compared against fully sampled MESE data. The proposed technique allows the assessment of T2 values in brain structures at high isotropic resolution.

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