Meeting Banner
Abstract #1259

Characterizing respiratory muscle composition and function in Duchenne muscular dystrophy using dynamic MRI and chemical shift-encoded imaging

Alison Marie Barnard1, Donovan Lott1, Abhinandan Batra1, William Triplett1, Sean Forbes1, Samuel Riehl1, Rebecca Willcocks1, Barbara Smith1, Krista Vandenborne1, and Glenn Walter2

1Department of Physical Therapy, University of Florida, Gainesville, FL, United States, 2Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL, United States

In Duchenne muscular dystrophy (DMD), respiratory muscle weakness leads to eventual respiratory failure. For this investigation, dynamic MRI was utilized to characterize diaphragm and chest wall dynamics during breathing, and chemical shift-encoded imaging was utilized to assess fatty infiltration in accessory respiratory muscles in 36 individuals with DMD and 12 unaffected controls. For maximal inspirations, individuals with DMD had significantly reduced anterior-posterior chest expansion, and a subgroup with poor respiratory function had decreased diaphragm descent (normalized to height). The expiratory muscles had high levels of fatty infiltration, and muscle fat fraction was correlated with measures of expiratory muscle strength.

This abstract and the presentation materials are available to members only; a login is required.

Join Here