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Abstract #1260

Can be Pi2 signal in 31P MR spectra a biomarker of critical limb ischemia in diabetic patients?

Petr Sedivy1, Monika Dezortova1, Miloslav Drobny1, Michal Dubsky2, and Milan Hajek1

1MR-Unit, Dept. Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2Dept. Diabetology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

A group of 65 diabetic patients with critical limb ischemia was studied by rest and dynamic phosphorous MR spectroscopy. An unknown signal in the position 5.2 – 5.4 ppm (labeled as Pi2) was observed in calf muscle spectra of 14 patients. Two hypotheses of the Pi2 signal explanation were taken into the consideration: a) phosphorus in alkaline phosphate pool or b) phosphorus in an unknown phosphomonoester. Results support hypothesis a) and we think that Pi2 signal at 5.4 ppm in patients with diabetic foot disease could be considered as the biomarker of the most severe muscular damage.

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