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Abstract #1261

Regional thigh muscle composition based on chemical shift encoding-based water-fat MRI and its association with muscle strength

Maximilian Thomas Löffler1, Sarah Schlaeger1,2, Stephanie Inhuber3, Michael Dieckmeyer1, Dominik Weidlich2, Ansgar Schwirtz3, Ernst J. Rummeny2, Claus Zimmer1, Jan S. Kirschke1, Dimitrios Karampinos2, and Thomas Baum1

1Department of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, 2Department of Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, 3Department of Sport and Health Sciences, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

Chemical shift encoding-based water-fat MRI derived proton density fat fraction (PDFF) of the thigh muscles bears potential as a surrogate marker in subjects with osteoarthritis, sarcopenia, and neuromuscular disorders. Muscle PDFF has shown to correlate with isometric strength at the thigh and spine. However, MR-based muscle fat quantification requires time-consuming segmentation of multiple muscle compartments. Therefore, we investigated if segmentation of single compartment muscles and of different levels of the thigh influences the relation of PDFF to isometric strength. The present study demonstrated that PDFF measurements can be limited to an entire muscle compartment, independent of sampling level.

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