Abstract #1271

Visualization of Aquaporin 4 using Time-dependent Diffusion MRI in Mouse Skeletal Muscle

Junichi Hata^1,2,3, Takayuki Obata⁴, Yasuhiko Tachibana⁴, Yawara Haga¹, Mai Mizumura¹, Daisuke Nakashima², Yasushi Sera², Masaya Nakamura², and Hideyuki Okano^1,2

¹Center for Brain Science, RIKEN, Wako, Japan, ²Keio University, Tokyo, Japan, ³Central Institute for Experimental Animals, Kanagawa, Japan, ⁴National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan

We focused on aquaporin 4 in skeletal muscle and attempted to visualize its function using time-dependent diffusion magnetic resonance imaging (MRI). In addition, the validity of the muscle cell type characteristics was evaluated by immunostaining. The diffusion time was adjusted with the PG-STE method using a 9.4-T MRI scanner. Diffusivity associated with a difference in the diffusion time was found to differ depending on the skeletal muscle type. Thus, it was possible to visualize the water molecule exchange rate of skeletal muscle cell membranes.

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