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Abstract #1271

Visualization of Aquaporin 4 using Time-dependent Diffusion MRI in Mouse Skeletal Muscle

Junichi Hata1,2,3, Takayuki Obata4, Yasuhiko Tachibana4, Yawara Haga1, Mai Mizumura1, Daisuke Nakashima2, Yasushi Sera2, Masaya Nakamura2, and Hideyuki Okano1,2

1Center for Brain Science, RIKEN, Wako, Japan, 2Keio University, Tokyo, Japan, 3Central Institute for Experimental Animals, Kanagawa, Japan, 4National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan

We focused on aquaporin 4 in skeletal muscle and attempted to visualize its function using time-dependent diffusion magnetic resonance imaging (MRI). In addition, the validity of the muscle cell type characteristics was evaluated by immunostaining. The diffusion time was adjusted with the PG-STE method using a 9.4-T MRI scanner. Diffusivity associated with a difference in the diffusion time was found to differ depending on the skeletal muscle type. Thus, it was possible to visualize the water molecule exchange rate of skeletal muscle cell membranes.

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