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Abstract #1272

Simulation based study of the effect of sub-voxel spatial distribution of permeability of muscle fibres as a function of diffusion time and b-value using a finite element model

Nadia A S Smith1, Jessica E Talbott1, Chris A Clark2, and Matt G Hall1,2

1National Physical Laboratory, Teddington, United Kingdom, 2UCL GOS Institute of Child Health, London, United Kingdom

We investigate the effect of the sub-voxel patterning of permeability in muscle tissue on the diffusion signal via a finite element simulation of diffusion MRI on a model of muscle tissue. We observe that permeability with a disordered pattern leads to statistically significant differences in diffusion signal at high b and longer diffusion times.

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