Abstract #1275

Extended phase graph model based tissue-water T2 estimation from CPMG image data in fat-infiltrated skeletal muscle: application in amyotrophic lateral sclerosis and Kennedy’s disease

Nick Zafeiropoulos¹, Uros Klickovic¹, Luca Zampedri¹, Stephen J Wastling¹, Christopher J Sinclair¹, Jasper M Morrow¹, Robert X Janiczek², Enrico De Vita³, Tarek A Yousry¹, Michael G Hanna¹, Linda Greensmith¹, Pietro Fratta¹, and John S Thornton¹

¹UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ²Glaxo Smith Kline, London, United Kingdom, ³Department of Biomedical Engineering, King’s College London, London, United Kingdom

An MRI CPMG extended phase graph signal model was used to determine muscle-water T₂ (T_2m) in fat-infiltrated skeletal muscle, using a fixed two-component approximation to the fat signal. Stable estimates of T_2m and apparent fat fraction (ff_a) in the thigh muscles of amyotrophic lateral sclerosis and Kennedy’s disease patients and healthy controls were obtained. T_2m were elevated in both patient groups, as was ffa with a distribution consistent with that obtained by 3-point Dixon MRI.

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