Diffusion MRI of skeletal muscle exhibits a transverse anisotropy, the source of which has yet to be conclusively determined. To explore this, histological images were segmented into intracellular and extracellular domains and used to inform a direct numerical simulation of the Bloch-Torrey equation. Histology images were examined at the myocyte and fascicle scale and it was found that results from the fascicle images exhibited increased transverse anisotropy. These results suggest that fascicle organization may pay a hereunto unrecognized role in affecting dMRI in skeletal muscle.
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