Abstract #1279

Semi-quantitative MR muscle analysis of VCP inclusion body myopathy

Saya Horiuchi^1,2, Hon J. Yu¹, Toshimi Tando¹, Taiki Nozaki², Vincent J. Caiozzo³, Virginia E. Kimonis⁴, and Hiroshi Yoshioka¹

¹Department of Radiological Sciences, University of California, Irvine, Irvine, CA, United States, ²Radiology Department, St. Luke's International Hospital, Tokyo, Japan, ³Department of Orthopedics and Physiology & Biophysics, University of California, Irvine, Irvine, CA, United States, ⁴Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California, Irvine, Irvine, CA, United States

This study was to demonstrate usefulness of semi-quantitative MR muscle analysis of VCP associated inclusion body myopathy associated with Paget and dementia (IBMPFD). Five-point scoring method was compared with quantification based on fat fraction analysis, and specific patterns of thigh muscle alterations were explored. The semi-quantification provided equivalent accuracy as quantification. The sartorius and adductor magnus were most affected by fatty infiltration, while the adductor longus and rectus femoris were well-preserved. Muscle volume decrease was more frequently seen in the hamstring and adductor muscles. This semi-quantitative method can be widely available in clinical settings and assist noninvasive initial/follow-up IBMPFD diagnosis.

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