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Abstract #1279

Semi-quantitative MR muscle analysis of VCP inclusion body myopathy

Saya Horiuchi1,2, Hon J. Yu1, Toshimi Tando1, Taiki Nozaki2, Vincent J. Caiozzo3, Virginia E. Kimonis4, and Hiroshi Yoshioka1

1Department of Radiological Sciences, University of California, Irvine, Irvine, CA, United States, 2Radiology Department, St. Luke's International Hospital, Tokyo, Japan, 3Department of Orthopedics and Physiology & Biophysics, University of California, Irvine, Irvine, CA, United States, 4Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California, Irvine, Irvine, CA, United States

This study was to demonstrate usefulness of semi-quantitative MR muscle analysis of VCP associated inclusion body myopathy associated with Paget and dementia (IBMPFD). Five-point scoring method was compared with quantification based on fat fraction analysis, and specific patterns of thigh muscle alterations were explored. The semi-quantification provided equivalent accuracy as quantification. The sartorius and adductor magnus were most affected by fatty infiltration, while the adductor longus and rectus femoris were well-preserved. Muscle volume decrease was more frequently seen in the hamstring and adductor muscles. This semi-quantitative method can be widely available in clinical settings and assist noninvasive initial/follow-up IBMPFD diagnosis.

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