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Abstract #1280

Quantitative evaluation of muscular microvascular permeability by DCE-MRI and texture analysis in diabetic rabbits

Bai Yu Liu1, Yun Fei Zha1, and Yang Fan2

1Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, China, 2GE Healthcare China, Beijing, China

Our purpose is to quantificationally evaluate the microvascular permeability and subtle changes in diabetic skeletal muscle by DCE-MRI and texture analysis. Alloxan-induced diabetic rabbits and normal rabbits were studied at fixed time points (0, 4, 8, 12, and 16 weeks). Permeability parameters Ktrans and Kep increased and then showed a downward trend, Ve increased and Vp decreased in diabetic group. Texture parameters based on Ktrans map showed difference between the two groups. We can draw a conclusion that the microvascular permeability of diabetic skeletal muscle increases while the perfusion decreases and texture analysis based on Ktrans map can detect these subtle changes in early stage.

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