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Abstract #1284

Mapping collagen and water proton densities in tibial cortical bone using 3D ultrashort echo time cones (3D-UTE-Cones) MR imaging techniques

Saeed Jerban1, Yajun Ma1, Tan Guo1, Lidi Wan1, Hyungseok Jang1, Liang Li1, Eric Y Chang1,2, and Jiang Du1

1Radiology, University of california, San Diego, San Diego, CA, United States, 2Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

Spatial variations of cortical bone microstructure and mechanics can be described by mapping proton densities as exist in macromolecular, bound, and pore water pools. Comparing bone signal in ultrashort echo time MRI (UTE-MRI) and in inversion recovery UTE MRI against a known external reference signal enabled us to measure total, bound, and pore water proton densities. Measured total water proton density combined with macromolecular fraction from magnetization transfer modelling resulted in macromolecular proton density estimation. We observed strong correlation between proton densities and bone porosity. The developed technique was performed robustly on ten young subjects. This technique may aid diagnosing bone diseases and injuries.

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