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Abstract #1285

Ultrashort echo time MRI (UTE-MRI) quantifications of cortical bone varied between scans at room temperature and body temperature

Saeed Jerban1, Nikolaus Szeverenyi1, Yajun Ma1, Tan Guo1, Sarah To2, Eric Y Chang1,2, and Jiang Du1

1Radiology, University of california, San Diego, San Diego, CA, United States, 2Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

Several quantitative ultrashort echo time MRI (UTE-MRI) techniques have recently been employed to assess cortical bone microstructure. Such techniques were examined mostly ex vivo at room temperature and demonstrated strong correlations with bone microstructure as measured with micro computed tomography (╬╝CT). However, MRI properties of cortical bone may differ in vivo due to higher temperature. We have investigated several UTE-MRI quantifications of cortical bone at body and room temperatures. Significant variations of bone UTE-MRI measures were observed between room and body temperatures. Implementing a linear correction method on UTE-MRI measures based on the presented results here might improve the validity of the techniques for in vivo studies.

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