Abstract #1294

Variation of ADC of skull bone marrow with age and pubertal status in a pediatric population

Erika Pace^1,2, Andrew D Mackinnon^2,3, and Nandita M deSouza^1,2

¹Cancer Research UK Imaging Centre, The Institute of Cancer Research, Sutton, United Kingdom, ²MRI Unit, The Royal Marsden Hospital NHS Foundation Trust, Sutton, United Kingdom, ³Department of Neuroradiology, Atkinson Morley Regional Neuroscience Centre, St George's University Hospitals NHS Foundation Trust, London, United Kingdom

ADC measurements were possible from the clivus of children. Values showed a significant negative correlation with age. Following puberty, there was a reduction in ADC and a left shift in centile histogram values, likely as a result of fat replacement. This was independent of gender. Bone marrow within the clivus behaves like marrow from tubular bones after puberty, and does not retain a cellular morphology expected from red hematopoietic bone marrow.

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