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Abstract #1294

Variation of ADC of skull bone marrow with age and pubertal status in a pediatric population

Erika Pace1,2, Andrew D Mackinnon2,3, and Nandita M deSouza1,2

1Cancer Research UK Imaging Centre, The Institute of Cancer Research, Sutton, United Kingdom, 2MRI Unit, The Royal Marsden Hospital NHS Foundation Trust, Sutton, United Kingdom, 3Department of Neuroradiology, Atkinson Morley Regional Neuroscience Centre, St George's University Hospitals NHS Foundation Trust, London, United Kingdom

ADC measurements were possible from the clivus of children. Values showed a significant negative correlation with age. Following puberty, there was a reduction in ADC and a left shift in centile histogram values, likely as a result of fat replacement. This was independent of gender. Bone marrow within the clivus behaves like marrow from tubular bones after puberty, and does not retain a cellular morphology expected from red hematopoietic bone marrow.

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