Abstract #1301

Quantitative Evaluation of Vertebral Marrow Fat content with Aging in Healthy Human using MRS and Dixon technique

Shao-Chieh Lin¹, Hou-Ting Yang², Yi-Jui Liu³, Hing-Chiu Chang⁴, Xiang-Wei Xie⁵, Wing P. Chang⁵, Yu-Chen Cheng¹, and Yi-Zong Liou¹

¹Master 's Program of Biomedical Informatics and Biomedical Engineering, Feng Chia University, Taichung City 407, Taiwan, ²Program of Electrical and Communications Engineering, Feng Chia University, Taichung City 407, Taiwan, ³Department of Automatic Control Engineering, Feng Chia University, Taichung City 407, Taiwan, ⁴Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, Hong Kong, Hong Kong, ⁵Department of Radiology, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan, Taipei, Taiwan

Subjects with osteoporosis have increased fat marrow, and fat content also increases progressively in the normal aging people. Although MRS has shown the potential probing the bone marrow content characteristics of the vertebra body in previous studies, all of them were a ROI analysis and loss local information. The purposes of this study were using MRS and Dixon technique to investigate the change of fatty marrow content with aging in human vertebra body. Our results have demonstrated the water-fat separation could quantitate vertebral marrow adiposity, which will be a potential method to provide local information for osteoporosis-related research fields.

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