Abstract #1302

Evaluating Gadolinium Deposition in Rabbit Cortical Bone by Using Ultrashort Echo Time T1 Mapping: Preliminary Results

Kaixuan Zhao¹, Shisi Li², Yingjie Mei^1,3, Qinqin Yu², Keyan Yu², Cuiling Zhu², Jian Wang², Hanwen Deng¹, Xiaodong Zhang², Jiang Du⁴, and Yanqiu Feng¹

¹School of Biomedical Engineering, Guangdong Provincial Key Laborary of Medical Image Processing, Southern Medical University, Guang Zhou, China, ²Imaging department of Southern Medical University affiliated the third hospital, Guang Zhou, China, ³Philips Healthcare, Guang Zhou, China, ⁴Department of Radiology, University of California San Diego, San Diego, California., San Diego, CA, United States

Gadolinium based contrast agents (GBCA) injection for enhanced MRI can induce gadolinium deposition in bones. In this work we investigated the feasibility of evaluating gadolinium deposition in rabbit cortical bone by using ultrashort echo time (UTE) T1 mapping at 7T. Lower T1 values were observed in the GBCA injection group than those in the control group (341±17.6ms vs. 450±10ms). This preliminary result indicates that UTE T1 mapping may be a feasible technique for evaluating bone gadolinium deposition.

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