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Abstract #1302

Evaluating Gadolinium Deposition in Rabbit Cortical Bone by Using Ultrashort Echo Time T1 Mapping: Preliminary Results

Kaixuan Zhao1, Shisi Li2, Yingjie Mei1,3, Qinqin Yu2, Keyan Yu2, Cuiling Zhu2, Jian Wang2, Hanwen Deng1, Xiaodong Zhang2, Jiang Du4, and Yanqiu Feng1

1School of Biomedical Engineering, Guangdong Provincial Key Laborary of Medical Image Processing, Southern Medical University, Guang Zhou, China, 2Imaging department of Southern Medical University affiliated the third hospital, Guang Zhou, China, 3Philips Healthcare, Guang Zhou, China, 4Department of Radiology, University of California San Diego, San Diego, California., San Diego, CA, United States

Gadolinium based contrast agents (GBCA) injection for enhanced MRI can induce gadolinium deposition in bones. In this work we investigated the feasibility of evaluating gadolinium deposition in rabbit cortical bone by using ultrashort echo time (UTE) T1 mapping at 7T. Lower T1 values were observed in the GBCA injection group than those in the control group (341±17.6ms vs. 450±10ms). This preliminary result indicates that UTE T1 mapping may be a feasible technique for evaluating bone gadolinium deposition.

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