Abstract #1314

T1ρ at low spin-lock amplitudes is more sensitive to degenerative changes in articular cartilage

Abdul Wahed Kajabi^1,2, Victor Casula^1,2, Juuso Ketola¹, Jaakko K. Sarin^3,4, Irina A.D. Mancini⁵, Jetze Visser⁵, Harold Brommer⁵, P. René Van Weeren⁵, Jos Malda^5,6, Juha Töyräs^3,4,7, Mikko J. Nissi^3,4, and Miika T. Nieminen^1,2,8

¹Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, ²Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, ³Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, ⁴Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland, ⁵Department of Equine Sciences, Utrecht University, Utrecht, Netherlands, ⁶Department of Orthopaedics, University Medical Center Utrecht, Utrecht, Netherlands, ⁷School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia, ⁸Department of Diagnostics Radiology, Oulu University Hospital, Oulu, Finland

In this study, continuous wave T_1ρ scans at various spin-lock amplitudes (γB₁ = 100, 200, 300, 400, 500, 600, 800, 1000 and 2000 Hz) were utilized to evaluate multiple articular cartilage regions at increasing distances from a surgically induced lesion in equine specimens. Significant differences were observed between regions adjacent and distant to the lesion, and the differences between the compared sites were larger at lower spin-lock amplitudes. The variations were in agreement with biomechanical properties (determined via indentation testing) of the regions. The findings suggest that T_1ρ at low spin-lock amplitudes is more responsive to progressive alterations in articular cartilage.

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