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Abstract #1314

T1ρ at low spin-lock amplitudes is more sensitive to degenerative changes in articular cartilage

Abdul Wahed Kajabi1,2, Victor Casula1,2, Juuso Ketola1, Jaakko K. Sarin3,4, Irina A.D. Mancini5, Jetze Visser5, Harold Brommer5, P. René Van Weeren5, Jos Malda5,6, Juha Töyräs3,4,7, Mikko J. Nissi3,4, and Miika T. Nieminen1,2,8

1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 2Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, 3Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, 4Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland, 5Department of Equine Sciences, Utrecht University, Utrecht, Netherlands, 6Department of Orthopaedics, University Medical Center Utrecht, Utrecht, Netherlands, 7School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia, 8Department of Diagnostics Radiology, Oulu University Hospital, Oulu, Finland

In this study, continuous wave T scans at various spin-lock amplitudes (γB1 = 100, 200, 300, 400, 500, 600, 800, 1000 and 2000 Hz) were utilized to evaluate multiple articular cartilage regions at increasing distances from a surgically induced lesion in equine specimens. Significant differences were observed between regions adjacent and distant to the lesion, and the differences between the compared sites were larger at lower spin-lock amplitudes. The variations were in agreement with biomechanical properties (determined via indentation testing) of the regions. The findings suggest that T at low spin-lock amplitudes is more responsive to progressive alterations in articular cartilage.

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