Chemical exchange saturation transfer of glycosaminoglycans (gagCEST) is a quantitative MR technique with potential for detecting early changes in cartilage composition. However, its relationship to tissue glycosaminoglycan (GAG) content has not yet been validated using standard biochemical assays. Here, we examine the relationship between gagCEST at 3T and 7T to cartilage biochemical properties using immature bovine femoral cartilage. Comparison of deep and superficial gagCEST asymmetry maps suggest that while gagCEST reflects the laminar differences in biochemical GAG composition, there is a weak correlation between gagCEST asymmetry and GAG content at 7T and 3T.
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