Meeting Banner
Abstract #1321

Assessment of Cartilage pH Using AcidoCEST-UTE MRI at 3T with Histological Correlation

Rachel High1,2, Yajun Ma2, Qingbo Tang2,3, Jonathan Wong2,3, Lidi Wan2, Jiang Du2, and Eric Y Chang2,3

1University of Arizona, Tucson, AZ, United States, 2Department of Radiology, University of California San Diego, San Diego, CA, United States, 3Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

The poor correlation between structural abnormalities of osteoarthritis (OA) and OA pain complicates treatment and pain management. Acidosis is heavily implicated in pain, and thus may be used to identify areas of pain not associated with structural damage. In this study, we used a pH-sensitive imaging method known as chemical exchange saturation transfer (acidoCEST) MRI to assess acidosis in cadaveric cartilage tissue and assess the relationship between pH and osteochondral vascularity as determined on histology. We show that acidoCEST MRI can measure extracellular pH (pHe) in cartilage, enabling further studies into the complex relationship between acidification, osteochondral channels, and pain.

This abstract and the presentation materials are available to members only; a login is required.

Join Here