Abstract #1323

T1ρ Relaxation of Human Articular Cartilage Using Time-fractional Order Model

Lixian Zou^1,2, Haifeng Wang¹, Yuanyuan Liu¹, Weitian Chen³, Yanjie Zhu¹, Dong Liang^1,4, and Xin Liu¹

¹Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Shenzhen, China, ³Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, HongKong, China, ⁴Research Center for Medical AI, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

T_1ρ imaging is a promising non-invasive diagnostic tool for early detection of articular cartilage degeneration. A mono-exponential model is normally used to describe the T_1ρ relaxation process. However, mono-exponentials may not adequately to describe NMR relaxation in complex, heterogeneous, and anisotropic materials, such as articular cartilage. Fractional-order models have been successfully used to describe complex relaxation phenomena in the laboratory frame in cartilage matrix components. In this work, we develop a time-fractional order (T-FACT) model to analyze T_1ρ relaxation in human articular cartilage. The results show the proposed method can better represent the T_1ρ relaxation in human articular cartilage.

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