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Abstract #1324

ARCADE: An efficient anisotropic $$$R_2$$$ relaxation mapping for human knee cartilage at 3T

Yuxi Pang1, Riann Palmieri-Smith2, Dariya Malyarenko 1, and Scott Swanson1

1Department of Radiology, University of Michigan, Ann Arbor, MI, United States, 2School of Kinesiology and Department of Orthopedic Surgery, University of Michigan, Ann Arbor, MI, United States

Water proton $$$R_2$$$ relaxation in cartilage at 3T contains both an isotropic and an anisotropic contributions, with the latter being more sensitive to degenerative changes. A composite relaxation ($$$R_2-R_{1ρ}$$$) mapping could be used to separate two contributions; however, its lengthy protocol had prevented it from being adopted in clinical applications. Here, we propose an efficient alternative based on a single T2W sagittal image to isolate an anisotropic $$$R_2$$$ and compare it with $$$R_2-R_{1ρ}$$$ on five live human knees. The comparable results demonstrate that the developed method could be easily used in clinical studies to characterize anisotropic $$$R_2$$$ of articular cartilage.

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