Abstract #1345

Creatine and phosphocreatine mapping of mouse skeletal muscle by a polynomial and Lorentzian line-shape fitting CEST method

Lin Chen^1,2, Peter B. Barker^1,2, Robert G. Weiss^2,3, Peter C. M. van Zijl^1,2, and Jiadi Xu^1,2

¹F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Kriger Institute, Baltimore, MD, United States, ²Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ³Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, United States

Wild type (WT) mice and Guanidinoacetate N-Methyltransferase deficiency (GAMT-/-) mice that have low Cr and PCr concentrations in muscle were used to assign the Cr and PCr peaks in the skeletal muscle Z-spectrum. A PLOF method was proposed to simultaneously extract and quantify the Cr and PCr CEST signal by assuming two Lorentzian functions for the Cr and PCr peaks and a polynomial function for the background signal. High-resolution PCr and Cr maps of mouse skeletal muscle were obtained by the PLOF CEST method after calibration with in vivo MRS.

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