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Abstract #1345

Creatine and phosphocreatine mapping of mouse skeletal muscle by a polynomial and Lorentzian line-shape fitting CEST method

Lin Chen1,2, Peter B. Barker1,2, Robert G. Weiss2,3, Peter C. M. van Zijl1,2, and Jiadi Xu1,2

1F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Kriger Institute, Baltimore, MD, United States, 2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 3Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, United States

Wild type (WT) mice and Guanidinoacetate N-Methyltransferase deficiency (GAMT-/-) mice that have low Cr and PCr concentrations in muscle were used to assign the Cr and PCr peaks in the skeletal muscle Z-spectrum. A PLOF method was proposed to simultaneously extract and quantify the Cr and PCr CEST signal by assuming two Lorentzian functions for the Cr and PCr peaks and a polynomial function for the background signal. High-resolution PCr and Cr maps of mouse skeletal muscle were obtained by the PLOF CEST method after calibration with in vivo MRS.

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