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Abstract #1346

Intramuscular magnesium measured by 31P-MRS is more closely associated with age and muscle function than is serum magnesium

Donnie Cameron1,2, Ailsa Welch2, Fatemeh Adelnia1, Christopher M. Bergeron1, David A. Reiter3, Nicholas A. Brennan1, Kenneth W. Fishbein1, Richard G. Spencer1, and Luigi Ferrucci1

1National Institute on Aging, National Institutes of Health, Baltimore, MD, United States, 2Norwich Medical School, University of East Anglia, Norwich, United Kingdom, 3Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States

We evaluate the relationships between muscle strength and intramuscular magnesium, measured by phosphorus magnetic resonance spectroscopy (31P-MRS), or serum magnesium. We further evaluate the relationships between these measures of magnesium status and age, sex, and muscle strength. Data were collected from participants in the Baltimore Longitudinal Study of Aging, a large cohort of normatively aging subjects encompassing a broad age range. Results showed that intramuscular magnesium was more closely associated with age and muscle function than was serum magnesium and may therefore represent a better clinical measure of magnesium status.

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