Abstract #1347

Spatial heterogeneities of calf muscle perfusion and its implications

Nan Hu¹, Xuenchen Wang², Christopher Conlin³, Xiaowan Li³, Christopher Hanrahan³, Gwenael Layec⁴, Lei Zhang⁵, and Vivian S Lee⁶

¹Internal Medicine, University of Utah Huntsman Cancer Institute, Salt Lake City, UT, United States, ²Population Health Sciences, University of Utah, Salt Lake City, UT, United States, ³University of Utah, Salt Lake City, UT, United States, ⁴University of Massachusetts at Amherst, Amherst, MA, United States, ⁵Radiology, University of Utah, Salt Lake CIty, UT, United States, ⁶Health Platform, Verily, Cambridge, MA, United States

For the study groups of young healthy subjects, aged healthy subjects and peripheral artery disease patients, we measured exercise-stimulated perfusion in calf muscles using both T1-weighted DCE MRI. We found that the heterogeneity and texture complexity of calf muscle (specifically, the medial gastrocnemius and soleus muscle groups) perfusion decreased with exercise load among the young healthy subjects, and decreased with age among all healthy subjects. In addition, the heterogeneity of the calf muscle perfusion is greater among young healthy subjects when compared with peripheral artery disease patients.

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