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Abstract #1347

Spatial heterogeneities of calf muscle perfusion and its implications

Nan Hu1, Xuenchen Wang2, Christopher Conlin3, Xiaowan Li3, Christopher Hanrahan3, Gwenael Layec4, Lei Zhang5, and Vivian S Lee6

1Internal Medicine, University of Utah Huntsman Cancer Institute, Salt Lake City, UT, United States, 2Population Health Sciences, University of Utah, Salt Lake City, UT, United States, 3University of Utah, Salt Lake City, UT, United States, 4University of Massachusetts at Amherst, Amherst, MA, United States, 5Radiology, University of Utah, Salt Lake CIty, UT, United States, 6Health Platform, Verily, Cambridge, MA, United States

For the study groups of young healthy subjects, aged healthy subjects and peripheral artery disease patients, we measured exercise-stimulated perfusion in calf muscles using both T1-weighted DCE MRI. We found that the heterogeneity and texture complexity of calf muscle (specifically, the medial gastrocnemius and soleus muscle groups) perfusion decreased with exercise load among the young healthy subjects, and decreased with age among all healthy subjects. In addition, the heterogeneity of the calf muscle perfusion is greater among young healthy subjects when compared with peripheral artery disease patients.

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