Meeting Banner
Abstract #1361

Intravoxel Incoherent Motion Outperforms Monoexponential and Kurtosis Models of Diffusion Attenuation in Normal and Inflamed Bone Marrow

Timothy JP Bray1, Alan Bainbridge2, Margaret A Hall-Craggs1, and Hui Zhang3

1Centre for Medical Imaging, University College London, London, United Kingdom, 2Magnetic Resonance Imaging Physics, University College London Hospitals, London, United Kingdom, 3Centre for Medical Image Computing, University College London, London, United Kingdom

Recently, there has been interest in the use of diffusion-weighted imaging (DWI) for quantifying inflammation of the skeleton. In spondyloarthritis, inflammatory exudates in the bone marrow increase the apparent diffusion coefficient (ADC), likely reflecting increased extracellular water. However, the ADC is a simplistic ‘summary’ measure and fails to disentangle the complex pathophysiological changes occurring at inflamed sites. Here, we show that the intravoxel incoherent motion (IVIM) model captures both the rapid ‘perfusion’ component and the slower ‘tissue’ components of the bone marrow diffusion signal, and thus provides a more accurate description of the signal than monoexponential and kurtosis models.

This abstract and the presentation materials are available to members only; a login is required.

Join Here