The first clinical application with zero echo time (ZTE) based MR bone depiction and segmentation in the temporomandibular joint (TMJ) was presented in this study. Our result revealed that ZTE showed computed tomography (CT)-like bone contrast and more detailed demonstration of bony structures, which contributed more reliable structure images and volume measurements. A potential alternative radiation-free diagnostic approach, especially for patients who receive initial workups or serial follow-ups, can be adopted to assess the staging of temporomandibular disorder (TMD) by segmenting cortical bone of the condyle into normal bone, erosion, and sclerosis.
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