Evidence has grown that disc degeneration may be influenced by cardiovascular risk factors. Thus, the purpose was to assess the association in a healthy sample from the general population. Disc degeneration as well as disc bulging and protrusion of the thoracic and lumbar spine was assessed using the Pfirrmann-score and correlated to risk factors such as obesity, hypertension and diabetes. Hypertension dependently while age and BMI independently associated with disc degeneration. Diabetes increased disc degeneration at Th7/8 and L3/4. Lifestyle conditions had no influence. In conclusion, certain cardiovascular risk factors are associated to disc degeneration and disc bulging and protrusion.