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Abstract #1382

Assessment of Multiple Myeloma pH Using AcidoCEST-FISP MRI at 7T

Rachel High1,2, Adam Searleman2, Yajun Ma2, Qingbo Tang2,3, Jonathan Wong2,3, Jiang Du2, Patrick Frost4, Mark D Pagel5, and Eric Y Chang2,3

1University of Arizona, Tucson, AZ, United States, 2Department of Radiology, University of California San Diego, San Diego, CA, United States, 3Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States, 4Research Service, Greater Los Angeles Veterans Administration Healthcare System, Los Angeles, CA, United States, 5Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, United States

Hypoxic conditions in multiple myeloma (MM) lesions drive anaerobic glycolysis and tumor acidosis, which contributes to tumor aggression and metastasis. In vivo imaging of acidosis in these lesions is important for determining the role of extracellular pH (pHe) in the pathology and spread of MM tumors. In this study, we use a novel imaging technique called chemical exchange saturation transfer (CEST) MRI to measure acidosis in vivo. We show that we are able to measure pH in MM lesions located in both vertebral bodies and regions of the knee using CEST MRI.

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