Hypoxic conditions in multiple myeloma (MM) lesions drive anaerobic glycolysis and tumor acidosis, which contributes to tumor aggression and metastasis. In vivo imaging of acidosis in these lesions is important for determining the role of extracellular pH (pHe) in the pathology and spread of MM tumors. In this study, we use a novel imaging technique called chemical exchange saturation transfer (CEST) MRI to measure acidosis in vivo. We show that we are able to measure pH in MM lesions located in both vertebral bodies and regions of the knee using CEST MRI.
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