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Abstract #1383

The parameters of Intravoxel Incoherent Motion Diffusion-Weighted Imaging for evaluating microstructure of bone marrow in myeloproliferative diseases: a Pilot Study

jinliang niu1, wenqi wu1, rong fan1, kaiyu wang2, and weiguo li3

1The second hospital of Shanxi Medical University, taiyuan, China, 2Healthcare,MR Research China, Beijing, China, 3Department of Radiology, Northwestern University, Chicago, American Samoa

Many myeloproliferativediseases,e.g., anemia and acute leukemia, impair microstructure of bone marrow. However, it is unclear the relationship between parameters of IVIM and microstructure of bone marrow (cellullarity, and microvessel density).Texture analysis was performed on D, D* and fmaps of the spinal bone marrow extracted from IVIM MRI on 48 patients (28 patients with acute leukemia and 20 patients with anemia). Bone marrow cellularity and MVD were significantly different between two groups. The f values in group of acute leukemia were significantly higher than that of anemia . The texture parameters of D, D* and f mapping has potential to reveal heterogeneous feature of microstructure in bone marrow.

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