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Abstract #1621

Variable Flip Angle T1 Consistency with and without Compensating for B1+ inhomogeneity in 3T Prostate MRI

Xinran Zhong1,2, Sepideh Shakeri1, Dapeng Liu1, James Sayre1, Steven S. Raman1, Holden H. Wu1,2, and Kyunghyun Sung1,2

1Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, 2Physics and Biology in Medicine IDP, University of California, Los Angeles, Los Angeles, CA, United States

Reliable pre-contrast T1 estimation is crucial for quantitative DCE MRI. Variable flip angle is widely used for pre-contrast T1 measurements and is sensitive to B1+ inhomogeneity. Although various B1+ techniques have been proposed, the application of B1+ compensation is not widely accepted yet. In this study, by evaluating T1 intra-scanner and inter-scanner consistency with and without B1+ compensation, we confirmed the necessity to perform B1+ compensation and a B1+ estimation method named reference region variable flip angle (RR-VFA) is recommended due to its consistent T1 estimation and wide availability.

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