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Abstract #1644

Amide proton transfer imaging for rectal cancer: correlation with IVIM, DCE MRI and 18F-FDG-PET/CT

Yuichi Kumagae1, Yoshihiko Fukukura1, Hiroto Hakamada1, Hiroaki Nagano1, Jochen Keupp2, Yuta Akamine3, and Takashi Yoshiura1

1Kagoshima University, Kagoshima, Japan, 2Philips GmbH Innovative Technologies, Research Laboratories, Hamburg, Germany, 3Philips Electronics, Japan, Tokyo, Japan

This study focused on the correlation between amide proton transfer (APT) imaging and IVIM, DCE MRI or 18F-FDG PET/CT in rectal cancer. Our results showed a significant positive correlation between APT signal intensity (APT SI) and SUVmax (p = 0.005, ρ = 0.547). No significant correlation was shown between APT SI and IVIM (ADC, f, D* or D) or DCE MRI parameters (Ktrans, Kep, Ve or Vp). These results suggested that APT imaging reflects some metabolism of the rectal cancer and may be useful for response prediction after chemotherapy.

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