Abstract #1644

Amide proton transfer imaging for rectal cancer: correlation with IVIM, DCE MRI and 18F-FDG-PET/CT

Yuichi Kumagae¹, Yoshihiko Fukukura¹, Hiroto Hakamada¹, Hiroaki Nagano¹, Jochen Keupp², Yuta Akamine³, and Takashi Yoshiura¹

¹Kagoshima University, Kagoshima, Japan, ²Philips GmbH Innovative Technologies, Research Laboratories, Hamburg, Germany, ³Philips Electronics, Japan, Tokyo, Japan

This study focused on the correlation between amide proton transfer (APT) imaging and IVIM, DCE MRI or ¹⁸F-FDG PET/CT in rectal cancer. Our results showed a significant positive correlation between APT signal intensity (APT SI) and SUVmax (p = 0.005, ρ = 0.547). No significant correlation was shown between APT SI and IVIM (ADC, f, D* or D) or DCE MRI parameters (K^trans, Kep, Ve or Vp). These results suggested that APT imaging reflects some metabolism of the rectal cancer and may be useful for response prediction after chemotherapy.

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