Abstract #1652

Multi-frequency spin echo- magnetic resonance elastography (SE-MRE) to non-invasively assess kidney allograft injury - preliminary findings

Eyesha Hashim¹, Prateek Kalra², Arunark Kolipaka², Darren Yuen^3,4,5, and Anish Kirpalani^1,6,7

¹Medical Imaging, St. Michael's Hospital, Toronto, ON, Canada, ²The Ohio State University, Columbus, OH, United States, ³Division of Nephrology, Department of Medicine, St. Michael's Hospital, Toronto, ON, Canada, ⁴|Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada, ⁵Division of Nephrology, Department of Medicine, The University of Toronto, Toronto, ON, Canada, ⁶Medical Imaging, University of Toronto, Toronto, ON, Canada, ⁷Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada

Chronic allograft injury (CAI) is typically indicated too late with blood work and its cause is determined invasively (e.g. via biopsy). It is thus important to develop non-invasively tools to identify CAI early. We used multi-frequency spin-echo magnetic resonance elastography (SE-MRE) to assess shear modulus as an estimate of CAI in a group of kidney allograft patients with stable but sub-normal graft function. We observed a negative trend approaching significance, between the graft function as determined by estimated glomerular filtration rate and the shear modulus at 90Hz suggesting that SE-MRE can potentially be used for non-invasive assessment of renal injury.

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