Abstract #1653

Towards systematic evaluation of velocity-selective ASL in the measurement of placental perfusion

Anita A. Harteveld¹, Jana Hutter², Suzanne L. Franklin^1,3, Laurence Jackson², Mary Rutherford², Joseph V. Hajnal², Matthias J. P. van Osch³, Clemens Bos¹, and Enrico De Vita²

¹Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ²Center for Biomedical Engineering, King’s College London, London, United Kingdom, ³C.J. Gorter Center for high field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

The placenta’s role as a nutrient and oxygen source for the fetus highly depends on blood supply and thus perfusion may be a sensitive marker of placenta function. Velocity-selective arterial spin labeling (VSASL) placental perfusion measurements have previously been demonstrated using standard parameter settings from the brain. In this study, the influence of different VSASL parameter settings was assessed to optimize measurement of placental perfusion. The results of this study will improve our understanding and interpretation of the measured perfusion signals in the placenta.

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