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Abstract #1653

Towards systematic evaluation of velocity-selective ASL in the measurement of placental perfusion

Anita A. Harteveld1, Jana Hutter2, Suzanne L. Franklin1,3, Laurence Jackson2, Mary Rutherford2, Joseph V. Hajnal2, Matthias J. P. van Osch3, Clemens Bos1, and Enrico De Vita2

1Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Center for Biomedical Engineering, King’s College London, London, United Kingdom, 3C.J. Gorter Center for high field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

The placenta’s role as a nutrient and oxygen source for the fetus highly depends on blood supply and thus perfusion may be a sensitive marker of placenta function. Velocity-selective arterial spin labeling (VSASL) placental perfusion measurements have previously been demonstrated using standard parameter settings from the brain. In this study, the influence of different VSASL parameter settings was assessed to optimize measurement of placental perfusion. The results of this study will improve our understanding and interpretation of the measured perfusion signals in the placenta.

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