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Abstract #1654

Delineating Benign from Malignant Breast Lesions Using Restriction Spectrum Imaging

Alexandra Besser1, Ana Rodriguez-Soto1, Hauke Bartsch1, Helen Park2, Andrew Park2, Haydee Ojeda-Fournier1, Anders Dale1, and Rebecca Rakow-Penner1

1Radiology, University of California San Diego, La Jolla, CA, United States, 2School of Medicine, University of California San Diego, La Jolla, CA, United States

Non-contrast diffusion MRI holds great potential to screen women for breast cancer. Restriction spectrum imaging (RSI) is an advanced diffusion-weighted imaging (DWI) technique that reflects the high nuclear to cytoplasm ratio observed in cancer cells. This abstract explores RSI as a technique to non-invasively identify malignant from benign masses on non-contrast MRI by measuring RSI cellularity index (RSI-CI). Biopsy-proven malignant masses demonstrate high cellularity index compared to benign lesions. In this pilot study, RSI differentiates malignant from benign masses without contrast imaging, and could prove useful as a screening tool.

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