Abstract #1663

MRI Relaxometry: Comparing R2* Values in Liver and Pancreas with respect to Disease Characteristics

Arthur Peter Wunderlich^1,2, Stephan Kannengießer³, Lena Kneller¹, Berthold Kiefer³, Holger Cario⁴, Meinrad Beer¹, and Stefan Andreas Schmidt¹

¹Dept. for Diagnostic and Interventional Radiology, Ulm University, Medical Center, Ulm, Germany, ²Section for Experimental Radiology, Ulm University, Medical Center, Ulm, Germany, ³Siemens Healthcare, Erlangen, Germany, ⁴Clinic for Pediatric and Adolescent Medicine, Ulm University, Medical Center, Ulm, Germany

To study pancreatic iron accumulation in liver overloaded patients with respect to disease characteristics, 116 patients were investigated at 1.5 T MRI with a prototype breathhold 3D GRE protocol with in-line R₂*calculation. Mean R₂* values were determined in liver and pancreas by manually drawn ROIs. Pancreatic R₂* values were correlated with liver R₂* in patient subgroups according to transfusion frequency. Pancreatic R₂* correlated significantly to liver R₂* for sporadic or frequently transfused patients, was normal in patients requiring no transfusion, and elevated in most regular transfused patients. After bone marrow transplant, most patients showed only slightly raised pancreatic R₂*.

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