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Abstract #1664

Quantitative dynamic contrast-enhanced MR imaging for prediction of the response to gemcitabine in pancreatic ductal adenocarcinoma: a preliminary study

TANG WEI1, Cai-xia Fu2, Wei LIU1, and Wei-jun PENG1

1Radiology, Fudan University Shanghai Cancer Center, Shang Hai, China, 2Siemens Healthcare, MR Collaborations NE Asia, Shanghai, China, Shang Hai, China

This study aimed to explore the feasibility of dynamic contrasted enhancement MRI (DCE-MRI) for predicting the response to gemcitabine in pancreatic ductal adenocarcinoma, as well as the influence of different region of interests (ROIs) on quantitative parameters. We compared the differences of DCE-MRI parameters between responders and non-responders. Kep based on periphery ROI was the best predictive marker, showed the highest areas under ROC curve (AUC) of 0.806. Quantitative DCE-MRI may be a feasible method, and the parameters are useful for the prediction of response to gemcitabine in patients with PAC. The positions of ROI influenced the DCE-MRI parameters.

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