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Abstract #1669

Extracellular volume fraction on Gd-EOB-DTPA-enhanced MRI for predicting overall survival in patients with metastatic pancreatic adenocarcinoma

Yoshihiko Fukukura1, Yuichi Kumagae1, Hiroto Hakamada1, Hiroaki Nagano1, Kiyohisa Kamimura1, Tomohide Yoneyama1, Masanoari Nakajo1, and Takashi Yoshiura1

1Kagoshima University Graduate School of Medical and Dental Sciences, kagoshima, Japan

This study focused on the potential of extracellular volume (ECV) fraction measured by Gd-EOB-DTPA-enhanced MRI as a prognostic factor in patients with metastatic pancreatic adenocarcinomas. The effect on survival of variables including age, sex, tumor location, tumor size, TNM factors, serum carbohydrate antigen (CA) 19-9 and carcinoembryonic antigen (CEA) levels and tumor ECV fraction was assessed in patients with metastatic adenocarcinoma. Our results showed that pancreatic adenocarcinoma with higher ECV fraction had better prognosis. Therefore, ECV fraction measured by MRI before and 5 min after Gd-EOB-DTPA administration may be a useful semiquantitative marker of patient prognosis in metastatic pancreatic adenocarcinoma.

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