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Abstract #1668

Usefulness of amide proton transfer imaging in the evaluation of autoimmune pancreatitis activity

Yoshihiko Fukukura1, Yuichi Kumagae1, Hiroto Hakamada1, Hiroaki Nagano1, Takashi Iwanaga2, Jochen Keupp3, Yuta Akamine4, and Takashi Yoshiura1

1Kagoshima University Graduate School of Medical and Dental Sciences, kagoshima, Japan, 2Department of Radiological Technology, Kagoshima University Hospital, Kagoshima, Japan, 3Philips GmbH Innovative Technologies Research Laboratories, Hamburg, Germany, 4Philips Electronics Japan, Tokyo, Japan

This study focused on the potential of amide proton transfer (APT) MR imaging at 3.0T as an objective imaging biomarker in patients with autoimmune pancreatitis (AIP). Correlation of serum immunoglobulin G4 (IgG4) levels with APT SI, the apparent diffusion coefficient (ADC) values or the maximum standardized uptake value (SUVmax) on 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) was evaluated in eleven patients with AIP. Our results showed a significant positive correlation between serum IgG4 levels and APT signal intensity (SI). Therefore, APT imaging might be useful for monitoring AIP activity.

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