Abstract #1738

Quantitative MRI to assess portal hypertension in cirrhosis patients at 3T

Chris R Bradley^1,2, Rob E Scott², Eleanor F Cox^1,2, Naaventhan Palaniyappan², Indra Neil Guha², Guruprasad P Aithal², and Susan T Francis^1,2

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom

We have previously validated MRI as a surrogate measure of Hepatic Venous Pressure Gradient (HVPG) at 1.5T using T₁ relaxation time and splanchnic haemodynamics. Here, we explore the use of quantitative 3T MRI to assess portal hypertension. A strong correlation between HVPG and fat suppressed IR SE-EPI T₁ (p<0.0001) and a correlation with superior mesenteric artery (SMA) velocity (p=0.02) was observed. MOLLI T₁ showed a weak correlation with HVPG (p=0.11) compared with SE-EPI (p<0.001) in a matched patient subset. A fat suppressed IR SE-EPI T₁ scheme and SMA velocity can be used as a surrogate for HVPG at 3T.

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