Liver fibrosis is prevalent in patients with chronic liver disease, and the early diagnosis of liver fibrosis is still challenging in clinical practice. In this study, the hepatocyte fraction (HepF) was calculated using the T1 value before and 20min after Gd-EOB-DTPA injection (hepatobiliary phase). Patients with severe liver fibrosis showed significantly higher T1 value and lower HepF value. In addition, HepF achieved the best performance in differentiation of liver fibrosis from non-fibrosis (AUC = 0.74), and mild liver fibrosis from severe liver fibrosis (AUC = 0.95), proving HepF can be a better noninvasive quantitative method for liver fibrosis evaluation.
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