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Abstract #1741

A Rapid MR Elastography Sequence with Spatial Saturation Pulses to Suppress Vascular Flow

Hui Wang1,2, Andrew T. Trout2, Jean A. Tkach2, Tom Cull3, Jonathan R. Dillman2, and Charles L. Dumoulin2

1Philips, Cincinnati, OH, United States, 2Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 3Philips, Cleveland, OH, United States

We describe a rapid fast field echo (FFE) Magnetic Resonance Elastography (MRE) pulse sequence for measurement of liver stiffness in reduced breath hold times (from 13.3s to 9.2s/slice). The key features of the sequence include: 1) modified motion encoding gradients to allow a shorter TR while maintaining appropriate synchronization with the period of the applied mechanical motion; 2) flow saturation pre-pulses to suppress ascending and descending vascular flow; and 3) SENSE reconstruction. Through validation in a gel phantom and subsequent measurement of liver stiffness in vivo, we demonstrate the effectiveness of the new pulse sequence.

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